Tag Archive | "lung cancer"

Common Causes of Lung Cancer

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There are a various risk factors that are linked to lung cancer. The most common known causes are as follows

Cigarette Smoking
Cigarette smoking is probably the most closely related link to developing lung cancer. A person who smokes two packs or more of cigarettes per day has a one in seven chance of developing lung cancer. Those that smoke one pack of cigarettes per day have a twenty-five times greater chance of developing lung cancer than a non-smoker. In addition, those people that smoke a pipe or cigar have a five times greater chance of developing lung cancer than a non-smoker.

The risk of developing lung cancer increases with the number of cigarettes smoked over your lifetime. Cigarette smoking damages the cells in your lungs. The moment you stop smoking, your lungs begin healing themselves, replacing damaged cells with healthy, normal cells. Your risk of developing lung cancer begins decreasing almost immediately when you quit smoking. Every year that you do not smoke, your chances of developing lung cancer drop further. By the fifteenth year, your chances of developing lung cancer are about the same as those of a person who has never smoked.

Secondhand Smoke
Also known as passive smoking, people exposed to secondhand smoke on a regular basis will have a higher risk of developing lung cancer, even if they do not smoke themselves. Studies have shown that those who live with a smoker have a 24 greater risk of developing lung cancer than most non-smokers. Doctors estimate that about 3000 lung cancer deaths a year are related to secondhand smoke.

Asbestos Exposure
Exposure to asbestos is another well-known cause of lung cancer and mesothelioma – cancer of the pleural lining of the lungs. Asbestos was widely used in construction and everyday products in the late 1800s through the 1960s. Asbestos separates into fine silica fibers that become trapped in the tissues of the lungs. Mesothelioma is inextricably linked to asbestos exposure. There are no reported cases of mesothelioma in people who were not exposed to asbestos either in the workplace or through their environment. A non-smoker who was exposed to asbestos has a five times greater risk of developing lung cancer than a non-smoker who was not exposed. Smoking increases the risk dramatically – a smoker who was exposed to asbestos has a risk of developing lung cancer that is 50 to 90 times greater than that of a non-smoker.

Radon Gas
It is estimated that about 12 of lung cancer deaths can be attributed to radon gas, a colorless, odorless gas that is a natural byproduct of the decay of uranium. The U.S. Environmental Protection Agency estimates that as many as 15 of homes in the United States have unsafe levels of radon gas, which will account for 15,000 to 22,000 deaths from lung cancer annually.

Air Pollution
Scientists estimate that as many as 1 of all lung cancer deaths are attributable to air pollution. They believe that prolonged exposure to very polluted air can raise the risks of developing lung cancer to about the levels of a passive smoker.

Major breakthrough in the understanding of cancer

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Hunting for Genetic Mutations and Cancer
The current paradigm in medical research holds that the cause of most cancers is a genetic mutation. For instance, according to the National Human Genome Research Institute NHGRI, an institute at the NIH, “all cancers are based on genetic mutations in body cells.” In fact, mutation hunting is big business. Just look at the NIH budget allocated to discoveries of genetic mutations, the number of biotech companies chasing genetic mutations, the magnitude of the licensing agreements between biotech and pharmaceutical companies aimed to utilize newly discovered genetic mutations, and the number of stories in the media on genetic mutations and their so-called “link” to disease. However, this huge effort and billions of dollars has produced few discoveries and little benefits to the public. The reason for this limited success is simple. The cause of cancer is not a genetic mutation.

The story of the BRCA1 gene is a typical example of mutation hunting.

The Mystery of BRCA1
Genes, in general, produce proteins, which are the building blocks of cells. The concentration of the protein is tightly regulated. A mutated gene produces an abnormal concentration of its protein, which may lead to disease. In 1994, Mark Skolnick, PhD, discovered the BRCA1 gene BRCA1 is short for BReast CAncer 1. Following the discovery, scientists observed an abnormally low level of the BRCA1 protein in breast cancer tissues. The BRCA1 protein is a cell cycle suppressor, which means that the protein prevents cell replication. This observation created a lot of excitement. At the time, scientists believed that they were on the verge of finding the cause of breast cancer. The reasoning was that breast cancer patients must have a mutated BRCA1 gene, which would explain the decreased production of the protein, and the excessive replication of breast cancer cells in tumors.

In the United States, 180,000 cases of breast cancer are diagnosed each year. However, the BRCA1 gene is mutated in less than 5 of these cases. In more than 95 of breast cancer patients the gene is not mutated.

So here is the mystery. If the gene is not mutated in the great majority of the breast cancer patients, why are the tumors showing low levels of the BRCA1 protein? Today, this is one of the biggest mysteries in cancer research.

The BRCA1 gene is not unique. Many normal non-mutated genes exhibit a mysterious abnormal increased or decreased production of proteins in cancer. Moreover, studies also report abnormal gene expression of normal genes in other diseases, such as atherosclerosis, obesity, osteoarthritis, type II diabetes, alopecia, type I diabetes, multiple sclerosis, asthma, lupus, thyroiditis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, atopic dermatitis, and graft versus host disease.

The Discovery
A virus is a collection of genes. To replicate, some viruses settle in the nucleus of the host cell and use the cell machinery to replicate. What is the effect of a viral gene on the production of cellular proteins?

Think of a gene as an assembly line of a protein. Like all assembly lines, the gene has two parts, a conveyor the gene coding section, and a control panel the gene promoterenhancer. Imagine a cellular shop that assembles a product called BRCA1. One of the many buttons on the control panel is called N-box. Pressing the button increases production. However, only a small number of operators called transcription factors, those who pass a special certification called the p300 test, have permission to press this button. What happens when a virus opens a shop across the street from the cellular shop called latent infection to produce its viral products? The control panel in the viral shop also has an N-box button. To start production, the virus begins to hire away some of the certified operators. What is the effect of this “hiring away” on the number of available BRCA1 units? The number decreases. Moreover, the decrease becomes apparent even before the virus starts production the “hiring away” is what creates the effect, not the viral proteins. The viral assembly line competes with the BRCA1 assembly line for the certified operators, and by hiring them away prevents the cellular shop from producing the optimum, or “healthy” number of BRCA1 units. The lower number of BRCA1 units leads to excessive cell replication and breast cancer. See a more technical description in a recent paper published in the European Journal of Cancer.

The infection with the latent virus causes abnormal production of other genes, and as a result, the development of other chronic diseases. This sequence of events easily explains why people who suffer from obesity are also more likely to suffer from diabetes, cancer, and heart disease, and why a recent large scale study found that a low-fat diet does not protect against breast cancer. It also explains another surprising observation that male pattern baldness is associated with heart disease and prostate cancer. In general, this sequence of events easily explains the numerous observations indicating a co-existence or co-morbidity of some chronic diseases.

This discovery was first described by Dr. Hanan Polansky in his book, Microcompetition with Foreign DNA and the Origin of Chronic Disease, published by The Center for the Biology of Chronic Disease.

To summarize the cause of cancer, and other chronic diseases, is not a genetic mutation, it’s an infection with a latent virus.

Reaction of the Scientific Community
What is the scientific community saying about Dr. Polansky’s discovery?

Consider what the famous heart surgeon and “Living Legend,” Michael E. DeBakey, said about the discovery, “The theory underlying the basic concept concerning the origin of chronic diseases presented by Dr. Polansky is most interesting, indeed fascinating Perhaps a symposium could be held to provide a forum for further discussions and critiques of this fascinating theory.”

Elena N. Naumova, PhD, Associate Professor, Department of Family Medicine and Community Health, Tufts University School of Medicine, said, “Dr. Polansky’s work compellingly demonstrates a framework that could bring together researchers from different fields. His proposed theory will work its magic by clarifying ambiguous definitions, identifying similarities and differences in various biological processes, and discovering new pathways I believe that Dr. Polansky’s book will catalyze the scientific learning process, promote interdisciplinary cross-fertilization, stimulate development of treatment strategies and drug discovery, and leave the reader inspired.”

Sivasubramanian Baskar, PhD, Senior Scientist from the National Cancer Institute, NIH, said, “At first, I wish to congratulate Dr. Hanan Polansky for his scientific bravery to take such a unique, novel approach to further stimulate our understanding of the origin and establishment of chronic diseases. The philosophy underscored is an excellent one … The amazing correlation between theoretical predictions and observed in vivo effects seems to bring us a step closer to a deeper understanding of such complex biologic processes.”

Marc Pouliot, PhD, Assistant Professor, Department of Anatomy and Physiology, Faculty of Medicine, Universit Laval, Canada, said, “The concept of microcompetition will change our approach in the study of chronic diseases and will furthermore give scientists a higher level of understanding in biology. Presentation of this concept undoubtedly provides a new set of opportunities for attacking chronic diseases They lead the way to new approaches in chronic disease treatment.”

Howard A. Young, PhD, Section Head, Cellular and Molecular Immunology Section, Laboratory of Experimental Immunology, National Cancer Institute, NIH, said, “In summary, Dr. Polansky is to be applauded for his attempt to provide a unifying basis for chronic diseases. His theories are stimulating and offer a basis for experimental testing and possible treatment.”

Michael J. Gonzalez, PhD, Professor, Medical Sciences, University of Puerto Rico, said, “I know this book will profoundly impact medical research, drug discovery, as well as natural therapies. I also believe it will benefit the scientific community and society in general by providing further means of treatment for conditions in which only palliative care is available.”

You can find more reactions and the biographies the scientists reacting to Dr. Polansky’s discovery on the publisher’s see link below.

Hope for Cure and Protection
The significance of Dr. Polansky’s discovery cannot be overstated. For the first time, we can start to feel a little better about these diseases. With his discovery, pharmaceutical and biotech companies can now start to design medications that will target the cause of the disease rather than its symptoms, and therefore, cure the sick and protect the healthy from these deadly diseases.

What are the main symptoms of Mesothelioma?

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The term Mesothelioma in medical terms is defined as form of cancer that
proliferates at a very fast rate after it has been diagnosed, which affects the mesothelial cells in the body. After detailed study of this disease by several scientists all over the world, it has been concluded that in most of the cases the reason is the direct contact with loose asbestos particles. This disease is generally known to be derived from an abnormality that arises from inhaling the loose asbestos particles suspended in the air for a very long time. The chances of the patients, diagnosed of mesothelioma, have very bleak chances of survival which is not more than one or two years and if it has been detected long back and rigorous medication has been started on the patient then the patient is likely to live for about five years.

There are three types of mesothelioma but the symptoms of the diseases
depend on their kinds. The symptoms vary from one-another but the general
symptoms that are found in patients suffering from different types of
mesothelioma are weight loss, chest pain, loss of appetite, short breath, plain cough and cough with blood. Diagnosing mesothelioma in its initial stages is not possible because symptoms surface very late and that, these symptoms are no special signs indicating the particular disease but are common for other diseases too.

Generally the symptoms of mesothelioma resemble to that to any other normal lung diseases. Most of the symptoms arise in the lungs, where the
mesothelial cells covering the lungs and the cavity between them are
affected due to prolonged inhalation of asbestos fibers. Consulting with the
physician is very necessary from time to time and necessary test must be
conducted to detect the disease.

The main symptom of mesothelioma is a constant pain in the chest which is
followed by short breaths and difficult breathing because of accumulation of
fluid in the chest, which makes breathing all the more difficult. Some of the other symptoms of the disease include abnormalities in the lungs, which can be diagnosed under proper supervision of the doctor with a chest CT-scan.

Basically, the disease of mesothelioma advances in four stages. In the first stage, begins the formation of the tumor in the area of lining of the lung and doesnt exceed from one side of the lung. And then in the second stage the tumor extends to other organs in the chest cavity, such as heart. Then in the third stage its extents to the other abdominal organs affecting all the other organs too. Finally in the fourth and the last stage the tumor extends to all parts of the body and affects all the parts adversely. These are some of the symptoms of the disease of mesothelioma, by which the disease can be tracked in the initial stages of its occurrence.

Mesothelioma – The Biological Behavior

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The biological behavior of the mesotheliomas can be predicted by their gross look, those shape and structures

solitary, discrete masses are generally benign, whereas those, which grow diffusely, are usually malignant.
Mesothelioma is a tumor emerging from mesothelial lining of serous cavities, most often covering of lungs the pleural cavity , rarely, in coverings of abdomen peritoneal cavity and covering the heart pericardial sac.

They are two types benign and malignant.

Mesothelioma Benign or Solitary.
Benign or solitary can also called by pleural fibroma. Exposures of asbestos play no role on the e etiology of benign mesothelioma. Entirely it consists of a solitary, circumscribed, small, firm mass and generally less than one inch in diameter. Dense fibrous tissues can be seen by cut the surface. The tumor is composed by predominantly of collage fibers and reticulin with interspersed fibroblasts. Unusual, mesothelial lined clefts are seen in the tumor. Benign mesothelioma causes tumor is associated with systemic syndrome of osteoarthropathy or hypoglycemia. Removal of the tumor is generally curative.

Mesothelioma Malignant or diffuse.
It is a highly malignant tumor with high mortality and it is rare. Usually after 20 to 40 years exposure to asbestos the tumor can be detected. Almost 90 percent of malignant mesotheliomas are asbestos related.

What Exactly Puts People at Risk for Mesothelioma?

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Mesothelioma is a very serious disease. One of the reasons it is so serious is that many people do not know what puts them at risk for mesothelioma. The basic risk of getting mesothelioma has to do with asbestos exposure. Asbestos is very common in many things and therefore it is not very difficult to be exposed to it.

The first cause is exposure to asbestos through ones occupation. This is very common in several different occupations. People who work in shipbuilding trades, asbestos mining and milling, the manufacturing of asbestos products such as textiles, insulation work in construction and building, and brake repair are at risk. There are also many other occupations that involve asbestos exposure. Men are often associated with higher mesothelioma risk because many of the asbestos-related jobs are often held by men.

Smoking increases the risk for mesothelioma tenfold. Mesothelioma is a cancer of the lungs, and the harmful chemicals in cigarette smoke damage the lungs beyond repair. When cigarette smoke is coupled with asbestos, the risks for developing mesothelioma and other lung cancers are increased greatly. Persons who smoke should make every effort to stop smoking in order to protect their lungs.

Environmental exposure to asbestos can also increase the risk of developing mesothelioma. Persons who live in neighborhoods near asbestos milling or manufacturing plants should be aware of the potential risk factors. Vermiculite, which is a non-asbestos mineral silicate, was mined at Libby Montana. It was later found to be heavily contaminated with asbestos. Many children played in the vermiculite slag heaps that were located throughout the town. These children later developed mesothelioma. There are 28 sites throughout the USA that received Libby mine vermiculite that have been selected for a community-wide evaluation of asbestos disease.

Another risk of developing mesothelioma is using products that contain asbestos. Asbestos is in a very large number of consumer products, including many that are used today. Products such as electric blankets, heat guns, curling irons, molding clays, deep fryers, slow cookers, frying pans, dry wall patch, fake fireplace logs, dry wall patch, and pipe wrap insulation could put one at risk. There are also many other products that contain, or have had exposure to, asbestos. There are many asbestos-containing products that have been banned by the Consumer Products Safety Commission. Unfortunately, there are still products that contain asbestos. It is a good idea to avoid using these products if possible, in order to reduce the risk of mesothelioma.

All About a Mesothelioma Lawyer

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When someone is diagnosed with mesothelioma, they may find that they need an attorney to help them with their case. This is a disease that is rare, and there is little to be said about the condition. The rate of this disease is on the increase and there are new lawyers that are trying to settle many cases for different people. They have stepped in for the rights of the people to help them with their case.

Many victims of this disease need to have a mesothelioma lawyer to help them with their fight. These lawyers and law firms will deal with the victims and their families to help them claim the right compensation that they deserve from the companies that are responsible for their problems. These lawsuits result in a lot of money being won by the families when the right lawyer or firm handles them.

Handling asbestos causes mesothelioma. This comes from working in an environment that is affected by this deadly material or by someone that is contracted to remove it. Most of the time, the workers are made clear of the dangers that can be caused by working with this type of material. However, some employers will allow little or no protection from the material when the employees are handling it. These workers are entitled to compensation for their work.
Today there are many mesothelioma lawyers to choose from and there are many that are right for you. Many of these lawyers have dealt with this type of suit in the past and know the correct way to handle it. Those people that are looking for a lawyer should choose someone with a good history and experience in this type of case. Most lawyers are happy to provide clients with information that may be helpful in using them for your services. They will show past cases with the names deleted to show proof of their victory.

It is a good idea to find out if the mesothelioma lawyer that you are looking into has won any of their cases or not. These elements can make all the difference when it comes to trying to find the right lawyer to help you with your situation. It is a good idea to do as much research as you can on the entire situation. You may be able to determine your future when you choose their right mesothelioma lawyer for you and your case.

When it comes to being sick with a disease that could have been prevented, it is hard to deal with. Finding the right mesothelioma lawyer to help you in your fight against these companies is a good start. You will be fighting for something that means so much to a lot of people and it will be worth it in the end.

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