We all heard of Absestos and the horrible consequences it has in our health. Asbestosis is “a form of lung disease pneumoconiosis” which causes interstitial fibrosis or scarring of the lungs.

Asbestosis is progressive and, for the most part, irreversible. Respiratory impairment worsens with time, even if exposure to asbestos has ceased. Asbestosis is usually found in asbestos workers and not in the general public. People with asbestosis have shortness of breath, often along with a cough. Asbestos cretes Mesothelioma, and Mesothelioma is a form of cancer which affects mesothelial tissue in the lungs, peritoneum or pericardium.

The biggest concern mesothelioma is that can arise both from visceral and parietal peritoneum. It is diagnosed in advanced stages in most cases, and it often takes considerable time to arrive at the correct diagnosis, as the mean symptoms-to-diagnosis time reported is 122 days. The most frequently reported initial symptoms are abdominal pain 35, anorexia, marked weight loss, and ascites ; less frequently night sweats and hypercoagulability. Clinical presentation with fever of unknown origin, intestinal obstruction, or surgical emergency due to acute inflammatory lesions have been reported. Mesothelioma cancer of the mesothelium is a disease in which cells of the mesothelium become abnormal and divide without control or order. They can invade and damage nearby tissues and organs. Mesothelioma treatment if mesothelioma attorneys texas.

Mesothelioma is defined as an ICD-O histology code of 9050-9053. Data are presented for a five-year time period. Mesothelioma cell viability was decreased in a dose-dependent manner by lovastatin 5 to 30 microM. These effects were not reversed by exogenous growth factors or cholesterol, but were reversed by addition of doses of micro mevalonate, confirming that lovastatin affected mesothelioma viability by inhibiting mevalonate synthesis. This is based on the fact that Mesothelioma is a cancer of the thin lining surrounding the lung and this disease is almost always fatal, often within a few months of diagnosis.

The scary part about this ilness, is that mesothelioma has a much longer latency period compared with lung cancer 40 years versus 15-20 years, and mesothelioma is therefore likely to be found among workers who were first exposed to asbestos at an early age. Mesothelioma is always fatal. Mesothelioma has also been found in individuals who were exposed to asbestos only once decades earlier. The only known cause of mesothelioma is asbestos. Mesothelioma has a much longer latency period compared with lung cancer 40 years versus 15-20 years, and mesothelioma is therefore more likely to be found among workers who were first exposed to asbestos at an early age. Mesothelioma is always fatal.

Exposure to asbestos has also been associated with an increased incidence of esophageal, kidney, laryngeal, pharyngeal, and buccal cavity cancers. As with other known chronic occupational diseases, disease associated with asbestos generally appears about twenty years following the first occurrence of exposure There are no known acute effects associated with exposure to asbestos. Exposure to ozone for several hours at relatively low concentrations has been found to significantly reduce lung function and induce respiratory inflammation in normal, healthy people during exercise. This decrease in lung function generally is accompanied by symptoms including chest pain, coughing, sneezing, and pulmonary congestion. Exposure to environmental tobacco smoke ETS is a significant cause of lung cancers in people who themselves do not use tobacco. Between 3000 and 6000 lung cancer deaths per year in the United States are caused by exposure to ETS.

Cancer Courage and Love By Lorraine Kember

Everyday we hear of people dealing with incredible sadness and loss and we wonder; how do they do it? Where do they find the courage the strength? We may even ask ourselves how we would cope under the circumstances. Sadly, we only become aware of the answer, when tragedy visits us and our own lives are thrown into turmoil.

When some one we love is diagnosed with a terminal cancer, life as we knew it changes forever. Suddenly we enter a new world, a world filled with helplessness, despair and fear of the unknown. We no longer walk aimlessly around shopping Malls; we walk the Hospital corridors and sit in chemotherapy waiting rooms and are shocked by the number of people afflicted by cancer. We can not help but wonder if one day we too may be a patient and we fear for our own mortality.

Sitting in a Chemotherapy ward is an experience not to be forgotten. Cancer has no respect for gender, age or wealth. There are people from every race, color and creed; rich, middle class and poor; and none of this makes the slightest difference. They are all untited in their suffering, fellow human beings on the same sad journey.

One can not bear witness to the incredible courage of those who have cancer, without being deeply affected. My husbands courage in the face of his terminal mesothelioma cancer held me in awe and I decided to do everything within my power to help him.

I learned about the stages and symptoms of his disease; the pain he would experience and ways to bring it under control, so that I could work with his doctors, to achieve for him, the best possible quality of life for what ever time he was granted. It was incredibly hard to wake each day with the knowledge that my husband was dying; my anticipatory grief often overwhelmed me but somehow I managed to carry on. One day a lady said to me, You are such a strong woman. and I wondered what had made her say that. I didnt feel strong, I felt like I was breaking.

Despite a prognosis of three to nine months, my husband survived for two years and was not bed bound until three short days prior to his death. My journey beside him as he traveled to the end of his life, has taught me many things, above all the true meaning of love and the strength of the human spirit.

Deep within ourselves there is strength and courage to sustain us in times of personal tragedy. I have come to realize that during my husbands illness, I was indeed strong. I may have staggered with the burden of my grief but I did manage to help my husband achieve a quality of life few thought possible considering the nature of his disease. And, thanks to the expertise and dedication of the Palliative Care Team, I was able to fulfill my promise to him that he would not die in hospital. His death at home was as loving, sharing and peaceful as anyone could wish for.

I have witnessed courage; that of my husband as he battled his disease and of my own as I stood beside him, determined to improve the quality of his life. The knowledge that I was successful in this has brought me much peace. My husbands illness and death have wounded me deeply yet I have emerged far stronger than ever before and gone on to achieve things I never thought possible.

My experience has taught me not to take life for granted and to live each day with thanks for the wonderful gift that it is. I have witnessed death; my awareness of the fragility of life, despite the strongest of wills strengthens my determination to grasp everything life offers me, with both hands.

Mesothelioma is caused by asbestos exposure. Asbestos is a substance found naturally. It is made of strong flexible fibres. It was used extensively in industry because the fibres are not affected by heat or chemicals and a poor conductor of electricity. It is estimated that over 5,000 products have or had asbestos in them.

Of the six types of asbestos, only four are used commercially. These are chrysotile, crocidolite, amosite and anthrophyllite. Of these, crysotile or white asbestos accounts for 99 used in USA. In it natural state or well contained and maintained in products, asbestos do not pose a real hazard. It is when asbestos is broken down and fibres are released that there is concern.

Asbestos fibres are very thin and sharp. The fibre is 2,000 times thinner than a human hair. It measures under 0.3 microns or one millionth of a millimetre in diameter and five microns in length. It is not visible with the naked eye or through a microscope.
When released, the fibres remain in the atmosphere for a long time and can be carried great distances. When the fibres are inhaled, they stick to the lung tissue and are not expelled by breathing out or coughing. Some remain in the lungs, others gravitate into the pleural lining.

Asbestos exposure can lead to disease and develops over a long period of time. Asbestos related diseases are asbestosis, pleural plaques and lung cancers. The lung cancer can be either cancer of the lung itself or mesothelioma, a cancer of the lung lining. These cancers can take between 20 and 50 years to develop.
A recent article in a UK Newspaper highlighted the case of a Hospital Consultant who developed mesothelioma. He cannot recall any exposure to asbestos. It may well be that he was inadvertently exposed to asbestos without his knowledge i.e. such as living in the vicinity of a factory that leaked asbestos into the atmosphere.

Professor Peto has shown that new cases of mesothelioma will continue to increase in the early part of the twenty first century. He also said, Every single person in the UK has asbestos in their lungs. It is the level of exposure that is important.

We also know that people who has a history of asbestos exposure has a greater risk of lung cancer if they smoked. In a survey in 1992, 2602 individuals with lung cancer were interviewed. One in eight was exposed to asbestos and of these a third still smoked. A US study suggested that non-smokers exposed to asbestos have a five times greater risk of lung cancer. If they smoked, then the risk increased by a factor of 11. Smoking and asbestos exposure increases the risk of developing lung cancer to 52 times that of the general population.

At present no one knows how many lung cancers are due to asbestos exposure because of the long latency period and that cigarette smoking remains the major cause. Mesothelioma, however, is caused by asbestos exposure and this has been the basis of numerous high value legal claims.

As for the future, in the USA and Europe, asbestos related diseases will gradually increase to a peak. Of concern, however, are areas of conflict. In the Middle East, when a building was bombed, or when numerous buildings were bombed during the invasion of Iraq, do we have any idea how much asbestos was released into the atmosphere?

We are, however, certain that during the 911 disaster, asbestos fibres were released. When the Twin Tower collapsed, there were 400 tons of asbestos in the structure. The toxic cloud that hung over Manhattan, contained high level of asbestos. It is estimated that over 100,000 people suffered asbestos exposure. The greatest exposure was amongst first responders. Deborah Reeve was the first to die from asbestos related disease after 911. She was a first responder and paramedic. She died in March 2005 from mesothelioma. This concerned experts because mesothelioma takes a very long time to develop. They concluded that her exposure must have been excessive.

A study result showed that 70 of recovery and rescue workers who were active during and after the World Trade Centre collapse had some form of respiratory problem. A six year follow up study showed that sufferers with respiratory problems continue to have the same ailments.
In the six years since the attacks, Nadler said, We have accumulated a mountain of evidence that thousands of those exposed are suffering from chronic respiratory disease and, increasingly, a variety of rare cancers.

Hopefully, as experts predict, within the next few years asbestos related diseases will peak and the annual new cases will drop. If not, could it be a sleeping dragon about to wake up?

Clinical research to treat malignant mesothelioma is very active and although no treatment has yet proved entirely successful, there exist a range of treatments available to individuals diagnosed with the disease. There are three types of standard treatments used to treat malignant mesothelioma which include surgery, radiation therapy, and chemotherapy.

Surgery
Surgery for malignant mesothelioma is divided into a number of sub-classes, which are specially designed to limit the disease for individuals with particular strains of the disease.

Extrapleural pneumonectomy is a severe form of surgery in which the entire lung and a portion of the lining of the chest, the diaphragm, and some or the entire sac which surrounds the heart is removed.

Wide local excision is a form of surgery which targets and removes the cancer and a limited amount of the healthy tissue surrounding the cancerous region.

Pleurectomy and decortication removes part of the covering of the lungs, as well as the lining of the chest and portions of the outside covering of the lungs.

The surgical procedure pleurodesis is a distinct technique insofar as it employs a blend of chemicals andor drugs to create an intentional scar between the layers of the pleura. Post surgery, the space created by the scar must be drained, using either a catheter or chest tube, and is then filled with a chemical which inhibits the accumulation of fluid in the pleura cavity.

Radiation
The second primary medical technique used to fight the development of malignant mesothelioma is radiation. Radiation therapy, as applied to malignant mesothelioma uses the same basic technology as other forms of medical radiation insofar as the technique employs high energy x-rays to kill cancer cells. The process is divided into two broad categories

External radiation therapy is a technique in which a machine sends radiation in a targeted stream at a certain portion of the body, and in so doing it kills the cancerous cells in its purview.

Internal radiation therapy, by contrast, uses not an external machine, but rather needles, seeds and catheters to place radioactive substance directly on or near the cancer. While the precise method of implementation will of course depend upon the type and stage of the illness, what is constant within this category is that the goal is to get the radiation placed directly onto the cancerous area and in so doing provide a more concentrated and directed dosage.

Chemotherapy
The third standard malignant mesothelioma treatment is Chemotherapy. Chemotherapy uses drugs which target cancer cells and stop them from dividing and thus prevent their growth.
In systemic chemotherapy, the drug can be taken by mouth or injected, but either way the goal is to have it reach cancer cells by means of the bodys own blood circulation system. In regional chemotherapy, the drug is placed directly onto the target area. And finally, combination chemotherapy involves the use of two or more anticancer drugs which can be administered either orally or through injection.

Malignant mesothelioma is a difficult disease for anyone to bear, however, educating oneself as to the options available is an important step for making the process more manageable.

What is mesothelioma?

Mesothelioma is cancer of the mesothelium. Like most cancers, mesothelioma involves the abnormal dividing of cells of a particular part of the body — in this case, the mesothelium. Mesothelioma is so deadly because it remains dormant for many years and then begins to rapidly expand. The cancer then begins to invade and damage nearby tissue, including the vital organs.

What is the mesothelium?

Many of the internal organs of the body are protected by a membrane called the mesothelium. This membrane actually consists of two layers of cells. The inner layer surrounds the organs, and the second is a sac surrounding the inner layer. When organs within this membrane must move, expand or contract — such as the heart, lungs, bladder, and so on, they are able to do so because the mesothelium produces a lubricating fluid between the two layers.

Mesothelioma most often begins in the pleura or peritoneum. The pleura surrounds the lungs and covers the chest cavity. The peritoneum covers most of the organs in the abdominal cavity. Other mesothelium tissue is also vulnerable to mesothelioma. These include the pericardium that surrounds and protects the heart; the tunica vaginalis testic which surrounds the internal male reproductive organs; and the tunica serosa uteri which is the membrane covering the internal reproductive organs in women.

Who is at greatest risk to develop mesothelioma?

Mesothelioma has a very specific cause – exposure to asbestos. During the first half of the previous century, right up until the mid 1970s asbestos was an important material used to insulate buildings, machines, heavy equipment, and a broad range of commercial applications. Because it was plentiful and inexpensive to mine, asbestos was used in many building products such as home insulation, floor, ceiling and roof tiles. It was also used in commonly found commercial products such as brake linings and pipe insulation.

This meant that millions of people were coming in contact with asbestos on a daily basis. And since the effects of exposure to asbestos fibre often do not become apparent for 30 or 40 years after prolonged exposure, companies and health officials were slow to recognize the dangers of asbestos. As a result, shipyard workers, men and women working in asbestos mines and mills, workers producing asbestos products, workers in the heating and construction industries, and virtually all other tradespeople were exposed to asbestos fibres for extended periods of time.

Today it is understood that anyone working with or near asbestos has an increased risk of developing mesothelioma, so there are strictly controlled limits of exposure in the work place. But since the dormancy period of mesothelioma can often be 30 or 40 years, there are millions of workers who are at risk because of their exposure in the decades before the safety controls were put in place.

What are the symptoms of mesothelioma?

Pleural mesothelioma – cancer of the pleura or lung lining – causes shortness of breath or chronic coughing. Other symptoms of pleural mesothelioma may include chest pain, chronic coughing, shortness of breath, fatigue, wheezing, hoarseness, weight loss, or blood in the phlegm from the lungs when coughing.

Peritoneal mesothelioma affects the lining around the stomach and intestines and is usually just as dangerous. Symptoms of peritoneal mesothelioma include pain or swelling in the abdomen, weight loss, bowel obstruction, anemia, and fever.

Many of the symptoms of mesothelioma can easily be mistaken for allergies or a common cold. Mesothelioma is often discovered when patients think they have one of these other common illnesses.

How Serious is Mesothelioma?

By the time most infected people become aware they have mesothelioma, it is no longer dormant and becomes extremely aggressive. In its active phase, mesothelioma can travel quickly, and is almost impossible to stop. There are treatments used to keep the patient comfortable, but there is currently no cure for mesothelioma. As many as 75 of those who develop the disease will lose their life within one year. The remainder may last for up to an additional six months.

This makes it extremely important to detect the disease before it enters its active phase.

How is mesothelioma diagnosed?

Mesothelioma is often not diagnosed until it reaches an advanced stage. This is because of its long dormancy period, and because once it becomes active the initial symptoms are similar to much more comman and less dangerous sicknesses such as colds or the flu. If a patient has a history of exposure to asbestos, then a complete physical examination is advised. This would normally include x-rays of the chest or abdomen and lung function tests. It might also include a CT or CAT scan or an MRI. Both of these tests give detailed pictures of areas inside the body.

If these tests indicate the probability of mesothelioma, then it is necessary to perform a biopsy to confirm the diagnosis. Doing a biopsy involves an oncology specialist taking a small sample of affected tissue and examining it under a microscope for signs of malignancy. Depending on the location of the affected tissue, doing a biopsy can be a relatively traightforward procedure. It normally involves the insertion of a small instrument into the suspect cavity. These surgical devices have both viewing and sample taking capabilities. So the oncologist or surgeon can look at the cavity from the inside, and then take tissue samples from different areas.

If mesothelioma is discovered, the initial tests are followed up with what is called “staging”. This involves more tests to determine how far the disease has spread.

How is mesothelioma treated?

Standard treatments include the normal options available to cancer patients surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined. If the mesothelioma is discovered at an early enough stage these treatments can sometimes be effective.

Among the treatments that are used in order to reduce the effects of the disease are oxygen, postural drainage and pain killers. Many alternative treatment methods are also being tested, including attempts to strengthen the body’s immune system. Gene therapy is also being tested in an attempt to attack the problem at the DNA level. Other treatments being tried and tested include homeopathy, herbs and acupuncture. Unfortunately none of these have been found to be very effective once the disease reaches its aggressive stage.

As with all cancers, early detection is the best defense against mesothelioma. Anyone who has been exposed to asbestos should be alert for symptoms and contact a doctor immediately. Detecting mesothelioma at the earliest stage possible greatly increases the chances of beating the disease.

The term Mesothelioma in medical terms is defined as form of cancer that
proliferates at a very fast rate after it has been diagnosed, which affects the mesothelial cells in the body. After detailed study of this disease by several scientists all over the world, it has been concluded that in most of the cases the reason is the direct contact with loose asbestos particles. This disease is generally known to be derived from an abnormality that arises from inhaling the loose asbestos particles suspended in the air for a very long time. The chances of the patients, diagnosed of mesothelioma, have very bleak chances of survival which is not more than one or two years and if it has been detected long back and rigorous medication has been started on the patient then the patient is likely to live for about five years.

There are three types of mesothelioma but the symptoms of the diseases
depend on their kinds. The symptoms vary from one-another but the general
symptoms that are found in patients suffering from different types of
mesothelioma are weight loss, chest pain, loss of appetite, short breath, plain cough and cough with blood. Diagnosing mesothelioma in its initial stages is not possible because symptoms surface very late and that, these symptoms are no special signs indicating the particular disease but are common for other diseases too.

Generally the symptoms of mesothelioma resemble to that to any other normal lung diseases. Most of the symptoms arise in the lungs, where the
mesothelial cells covering the lungs and the cavity between them are
affected due to prolonged inhalation of asbestos fibers. Consulting with the
physician is very necessary from time to time and necessary test must be
conducted to detect the disease.

The main symptom of mesothelioma is a constant pain in the chest which is
followed by short breaths and difficult breathing because of accumulation of
fluid in the chest, which makes breathing all the more difficult. Some of the other symptoms of the disease include abnormalities in the lungs, which can be diagnosed under proper supervision of the doctor with a chest CT-scan.

Basically, the disease of mesothelioma advances in four stages. In the first stage, begins the formation of the tumor in the area of lining of the lung and doesnt exceed from one side of the lung. And then in the second stage the tumor extends to other organs in the chest cavity, such as heart. Then in the third stage its extents to the other abdominal organs affecting all the other organs too. Finally in the fourth and the last stage the tumor extends to all parts of the body and affects all the parts adversely. These are some of the symptoms of the disease of mesothelioma, by which the disease can be tracked in the initial stages of its occurrence.